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Forsigtighed ved søvnapnø (korte perioder med pauser i vejrtrækningen less than søvn). Dosis skal muligvis sænkes. quickly smertebehandling med depotpræparater presents fejlagtigt kun som p.n. Patienten bliver ikke smertedækket optimalt og risikoen for komplikationer øges (gennembrudssmerter, delir hos ældre mm.). Bemærk der er sket alv